9 Anti-Acne Serums with 5-Star Reviews for Oily & Acne-Prone Skin



We combed through multiple skincare sites to bring you this list of anti-acne serums with amazing ingredients and reviews for keeping your oily and acne-prone skin under control. Say goodbye to annoying imperfections — let's begin!



1. COSMEDIX Clarity Skin-Clarifying Serum


The COSMEDIX Clarity Skin-Clarifying Serum is formulated to exfoliate, calm, and treat agitated and problematic skin. It contains Salicylic Acid and Tea Tree Oil that could penetrate your skin to dissolve pore-clogging debris while reducing red, inflamed pimples at the same time. Aloe Vera and L-Retinol A are further added to the blend for additional skin-soothing and brightening benefits.


"Amazing, skin-saving product." — Buyer's review


2. SkinCeuticals Blemish + Age Defense


Designed to fight acne by diminishing P.acnes bacteria and reduce the appearance of fine lines and wrinkles, this oil-free acne treatment from SkinCeuticals is fortified with all the wonderful ingredients — Dioic Acid, Salicylic Acid, Glycolic Acid to deliver what it promises.


"It staves off any adult acne while reducing wrinkles, truly a win-win!!" — Buyer's review


3. La Roche Posay Effaclar Serum


This is an extremely lightweight, fast-absorbing serum that definitely packs a punch. The Effaclar Serum is a powerful skin-refining product that helps to decongest your pores, promote exfoliation, and rapid skin-clearing with 7.5% Glycolic Acid and 0.5% Lipohydroxy Acid (a derivative of Salicylic Acid).


"I’ve been using this product for many years, and I wouldn’t be without it! I have somewhat oily skin, and this product makes my skin tone even and helps keep my pores clean." — Verified Buyer's review


4. Mario Badescu Anti Acne Serum



While you focus on combatting acne, don't forget that your skin still needs its hydration. The Anti Acne Serum from Mario Badescu is formulated with Salicylic Acid, Thyme Extract, and Glycerin to reduce the acne-causing bacteria on the skin while working to balance and hydrate your troubled skin to encourage a healthy-looking complexion.


"I would definitely buy this over and over I have teen acne and I'm just so tired of looking at it and I use this stuff along with some other products and my tiny pimples and the irritation went down the next day!!" — Verified Buyer's review


5. Dermalogica Clear Start Breakout Clearing Booster



The Breakout Clearing Booster from Dermalogica is a daily acne treatment that aims to clear your breakouts fast while preventing skin dryness with Salicylic Acid and Phytoplankton Extract. This vegan and cruelty-free booster also contains Niacinamide to reduce inflammation and minimize pores for clearer and smoother skin.


"So I use this after cleansing, exfoliating, toning and a serum and I've noticed since I've added it to my routine it just has helped so much with my oily, acne prone skin." — Buyer's review


6. PAYOT Pate Grise Concentré Anti-Imperfections - Clear Skin Serum


The PAYOT Clear Skin Serum contains Glycolic Acid and Zinc Extract that greatly benefits blemish-prone skin by eliminating the build-up of oils and dead skin cells on your skin and prevent future scarring. Furthermore, this serum comes in an expert pipette bottle that delivers the exact amount of product to keep your pimples at bay!


"Lightweight yet powerful." — Verified Buyer's review


7. Estee Lauder Clear Difference Advanced Blemish Serum



This anti-blemish serum targets mild to moderate acne with Witch Hazel and 0.5% of Salicylic Acid. We love that it gives our skin a soft, matte finish after application which makes it perfect for day use and allows makeup to stay longer. This product is also formulated with Glucosamine that accelerates wound healing and prevent moisture loss.


"I've been using Clear Difference for almost 1.5 years and I can't complain. It's on my daily routine to keep mild acne at bay. Non irritating and effective." — Verified Buyer's review


8. Derma E Anti-Acne Acne Blemish Control Treatment Serum


This vegan and cruelty-free, blemish-control serum from Derma E got our attention with it's numerous 5-star reviews & ratings from its customers. It targets and fights breakouts, cystic acne and blackheads - a.k.a all of our pesky skin problems, kudos to its anti-blemish complex that contains Tea Tree Oil, Salicylic Acid, Willow Bark, Lavender and Chamomile.


"Love this product! Helping my cystic acne tremendously. Would highly recommend." — Verified Buyer's review


9. Juice Beauty Blemish Clearing Serum



The Juice Beauty Blemish Clearing Serum has a unique blend of organic apple and lemon juice with Green Tea extracts and Salicylic Acid (0.75%). This antioxidant serum promises to clear breakouts and unclog pores without the use of harsh benzoyl peroxide and petroleum derivatives.


"I've been using this product for a while now, and it has always worked super well in helping me control and minimize my acne." — Verified Buyer's review





About us: We are Skintelligence, a team focused on a 'skin-first' approach to beauty through artificial intelligence. We match products to you based on your unique skin type and needs. Results are highly accurate and personalized with AI and machine learning. It's fun, convenient, and it works. Try it here.


As featured in Her World, CLEO, FEMALE, Shape, Nuyou, Singapore Women’s Weekly, Daily Vanity, Layers of Skins.







Smart Skin Consultant.

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